HCID 12019228, compound → HCID 69538618, compound

HRID 2304386Notes

Reaction equation

HRID 2304386 reaction equation
[S:1](=[O:29])(=[O:28])([O:3][C:4]1[CH:21]=[CH:20][C:19]2[C@@H:18]3[C@H:9]([C@H:10]4[C@@:14]([CH2:16][CH2:17]3)([CH3:15])[C@@H:13]([C:22](=[O:27])[NH:23][CH2:24][CH2:25]C)[CH2:12][CH2:11]4)[CH2:8][CH2:7][C:6]=2[CH:5]=1)[NH2:2].S(=O)(=O)(OC1C=CC2[C@@H]3[C@H]([C@H]4[C@@](CC3)(C)C=CC4)CCC=2C=1)N>>[S:1](=[O:28])(=[O:29])([O:3][C:4]1[CH:21]=[CH:20][C:19]2[C@@H:18]3[C@H:9]([C@H:10]4[C@@:14]([CH2:16][CH2:17]3)([CH3:15])[C@@H:13]([C:22](=[O:27])[NH:23][CH2:24][CH3:25])[CH2:12][CH2:11]4)[CH2:8][CH2:7][C:6]=2[CH:5]=1)[NH2:2]

Participants

3

Reactant 2

HCID 12019228HCID 12019228, compoundHCID 131723439HCID 131723439, compound

Product 1

HCID 69538618HCID 69538618, compound

Procedure

In similar manners to those described for the synthesis of compound 7, compound 29g was prepared from compound 11g. FAB-MS m/z 407 (M+H)+; 1H NMR (270 MHz, DMSO-d6) δ 0.60 (s, 3H, CH3), 1.01 (t, 3H, J=7.3 Hz, CH2CH3), 3.02 (m, 1H, CH2CH3), 3.16 (m, 1H, CH2CH3), 6.96 (d, 1H, J=2.0 Hz, ArH), 7.01 (d, 1H, J=8.6 Hz, ArH), 7.34 (d, 1H, J=8.6 Hz, ArH), 7.47 (t, 1H, J=5.6 Hz, NHCH2), 7.87 (s, 2H, NH2).

Sources & evidence

ORD record
ord-fe6f7c93d34a41bb9ec4781f121c220c
Source dataset
uspto-grants-2002_08
Patent number
US06436918B1

Reaction notes

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