反应详情

A hydrogen chloride ether saturated solution was added to a solution of 12.0. g (23.2 mmols) of (S)-(−)-5,11-dihydro-5-(1-(4-methoxyphenethyl)-2-pyrrolidinylmethyl]dibenzo[b,e][1,4]oxazepine in 50 ml of dichloromethane, and the mixture was stirred for 5 minutes. Then, the solvent was distilled off under reduced pressure. The resulting residue was recrystallized from a mixed solvent of acetone and diethyl ether to give 9.5 g of (S)-(−)-5,11-dihydro-5-[1-(4-methoxyphenethyl)-2-pyrrolidinylmethyl]dibenzo[b,e][1,4]oxazepine hydrochloride as a colorless prism crystal in a yield of 73%.

1. distillationThen, the solvent was distilled off under reduced pressure
2. customThe resulting residue was recrystallized from a mixed solvent of acetone and diethyl ether