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HRID2304406

反应详情

EQUATION

反应方程式

HRID 2304406 的结构方程式

REACTANTS

反应物

2
结构：c1ccc2c(c1)COc1ccccc1N2
HCID11084798

5,11-Dihydrodibenzo[b,e][1,4]oxazepine

C13H11NO

结构：COCO[C@@H]1C[C@H](Cl)CN(CCc2ccc(OC)cc2)C1
HCID15481952

未命名化合物

PRODUCTS

生成物

1
结构：COCO[C@@H]1C[C@H](CN2c3ccccc3COc3ccccc32)N(CCc2ccc(OC)cc2)C1
HCID15481938

未命名化合物

PROCEDURE

实验过程

(3S, 5R)-(+)-3-chloro-5-(methoxymethoxy)-1-(4-methoxyphenethyl)piperidine was coupled with 5,11-dihydrodibenzo[b,e][1,4]oxazepine as described in Example 1 to give (+)-5,11-dihydro-5-[[(2R, 4R)-4-(methoxymethoxy)-1-(4-methoxyphenethyl)pyrrolidin-2-yl]methyl]dibenzo[b,e][1,4]oxazepine in 4.30 g (72.6%) yield as pale yellow oil.