Benzene → HCID 69736425, compound

Participants

Reaction Steps

N-(Toluene-4-sulfonyl-L-prolyl-(4-nitro)phenylalanine methyl ester was mixed with an equimolar amount of PCl5 in dry benzene and stirred for 90 minutes. The yellow solution was treated with a solution of hydrazoic acid in benzene and the mixture was stirred at room temperature for 2 hours, then it was diluted with benzene and washed with satd. NaHCO3 and brine. The organic layer was dried and evaporated to give a light yellow foam. The title compound was prepared from the product of the last reaction using standard basic hydrolysis techniques, yielding an off-white fluffy solid, mp 150-160° C.

Provenance & Evidence