Benzocaine → HCID 178468800, compound

Participants

Reaction Steps

This compound was prepared using 121 mg (0.5 mmol) of 4-(N′-dicyanomethylene-hydrazino)benzoic acid ethyl ester, which was derived from ethyl 4-aminobenzoate (165 mg, 1.0 mmol) and malononitrile (1.5 mmol) as described in Example 8, and hydrazine hydrate. The hydrazine hydrate was added to the solution at a temperature of 75° C. The solution cleared briefly and then a precipitate formed. The resulting solid was isolated by filtration, washed with ethanol, and dried to yield 45 mg (33%) of the title compound as a yellow solid.

Provenance & Evidence