Water → HCID 12873688, compound

Participants

Reaction Steps

50 g (0.22 mol) of ethyl 2-bromobenzoate, 30 g (0.29 mol) of 4-vinylpyridine and 75 ml (0.54 mol) of triethylamine were dissolved in 750 ml of dimethylformamide. Then 0.36 g of palladium(II) acetate, 0.96 g of tri(o-tolyl)phosphine and 1 ml of water were added and the mixture was refluxed for 3 h. The reaction mixture was then poured into ice-water and extracted with ethyl acetate. The organic phase was dried and concentrated in vacuo. The residue was recrystallized [lacuna] cyclohexane/petroleum ether, resulting in 45.3 g (83%) of the product.

Provenance & Evidence