2-Chloro-3-quinolinecarboxaldehyde → (2-Chloroquinolin-3-yl)methanol

Participants

Reaction Steps

A suspension of 2-chloro-3-quinolinecarbaldehyde (19.2 g, 100 mmol) in methanol (400 ml) is treated with sodium borohydride (5.7 g, 150 mmol). After agitation for 2 hours at ambient temperature, the reaction medium is concentrated under reduced pressure then taken up in water, filtered, washed with water and with ethanol in order to produce, after drying under reduced pressure, 15.8 g (81%) of a white solid, m.p. 166° C.

Provenance & Evidence