Dimethylformamide → HCID 9806224, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 4-phenyl-4-cyanopiperidine (328 mg, 1.76 mmol) and 3-bromopropyl-5,5-bis(4-methylphenyl)-imidazolin-2,4-dione (603 mg, 1.5 mmol) in dry dimethylformamide (3 mL) containing triethyl amine (0.28 mL, 2.0 mmol) was warmed at 50° C. for four hours. The cooled reaction mixture was diluted with ethyl acetate. This solution was washed with aq. Na2CO3, water (3×), and then dried over anhydrous Na2SO4,filtered through a pad of charcoal and the solvent evaporated. The residue was triturated with methanol to give pure crystalline product. m.p.: 157-159° C.

Provenance & Evidence