4-Fluoroaniline → HCID 23440846, compound

HRID 2304644Notes

Reaction equation

HRID 2304644 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:9][CH2:10][C:11](Cl)=[O:12])[CH:6]=[CH:7][CH:8]=1.[F:14][C:15]1[CH:21]=[CH:20][C:18]([NH2:19])=[CH:17][CH:16]=1>>[F:14][C:15]1[CH:21]=[CH:20][C:18]([NH:19][C:11](=[O:12])[CH2:10][CH2:9][C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[CH:4]=2)=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 97314-FluoroanilineHCID 12584679HCID 12584679, compound

Product 1

HCID 23440846HCID 23440846, compoundYield 97.2%

Procedure

The title compound was prepared as described in Example 1.A, using 3-methoxyphenylpropionylchloride (6.62 g, 33.3 mmol) and 4-fluoroaniline (3.70 g, 33.3 mmol) to afford N-(4-fluorophenyl)-3-(3-methoxyphenyl)propanamide (8.85 g, 97% yield): ES-MS (m/z) 273.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-bbf5551f02454500b7a2eb23b0719bfa
Source dataset
uspto-grants-2002_08
Patent number
US06436923B1

Reaction notes

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