Imidazole → HCID 153274962, compound

Participants

Reaction Steps

0.25 g of bis(4-fluoro-3-trifluoromethylbenzoyl)guanidine, 0.16 g of imidazole and 0.16 g of potassium carbonate are heated for 16 h in 5 ml of DMF, and after that the solvent is evaporated. Separation of the crude product by column chromatography yielded 0.12 g of bis[4-(1-imi-dazolyl)-3-trifluoromethylbenzoyl]guanidine as a colorless solid, mp 130° C., decomp., Rf (CH2Cl2/MeOH 9:1)=0.4 MS (ES): 536 (M+1) and 0.07 g of N-[4-(1-imidazolyl)-3-trifluoromethylbenzoyl]-N′-(4-fluoro-3-trifluoromethylbenzoyl)guanidine as an oil. Treatment with HClg/ether yielded 0.06 g of N-[4-(1-imidazolyl)-3-trifluoromethylbenzoyl]-N′-(4-fluoro-3-trifluoromethylbenzoyl)guanidine hydrochloride as a colorless solid, mp 217-218, decomp., Rf (CH2Cl2/MeOH 9:1)=0.53; MS (ES): 488 (M+1)

Provenance & Evidence