HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 3-Propyl-4-bromo-5-aminobenzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 3-Propyl-5-aminobenzimidazole | HCID 18379870 | — |
| Reactant | Dichloromethane methanol | HCID 21226129 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 3-Propyl-4-bromo-5-aminobenzimidazole | HCID 18379895 | 37% |
Reaction Steps
To a solution of 3-propyl-5-aminobenzimidazole (0.71 g, 4.3 mmol) in 10 ml of AcOH was added solution of Br2 in AcOH until it produces a precipitation. The reaction mixture was concentrated in vacuo to provide a brown solid which was subjected to column chromatography (5% NH3 sat'd MeOH/CH2Cl2) to provide 0.40 g (1.6 mmol, 37%) of the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06436982B1 |
| Source dataset | uspto-grants-2002_08 |
| ORD ID | ord-48eabc4fff1f43528f93eee7efb67de5 |
| Source note | uspto-grants-2002_08 |