Bromine → 1-Isobutyl-4-bromo-5-aminobenzimidazole

Participants

Reaction Steps

To a solution of 1-isobutyl-5-aminobenzimidazole (2.4 g, 13 mmol) in 20 ml of AcOH was added solution of Br2 in AcOH until it produces a precipitation. The reaction mixture was concentrated in vacuo to provide a brown solid which was subjected to column chromatography (5%) NH, sat'd MeOH/CH2Cl2) to provide 1.2 g (4.5 mmol, 35%) of the product.

Provenance & Evidence