反应详情

温度

25 °C

To a solution of 3.2 g (16 mmol) of 2-trifluoromethyl-5-aminobenzimidazole in 50 ml of AcOH was added 0.34 ml (6.6 mmol) of Br2 dropwise and resulting reaction mixture was stirred for 1 h at 25° C. The reaction mixture was concentrated in vacuo and purified on silica gel column chromatography (10% MeOH/CHCl3) to yield 1.7 g (6.2 mmol, 94%) of the desired product.

1. customresulting
2. customreaction mixture
3. concentrationThe reaction mixture was concentrated in vacuo
4. custompurified on silica gel column chromatography (10% MeOH/CHCl3)