Malic Acid → HCID 131723443, compound

Participants

Reaction Conditions

Reaction Steps

N-2-Ethylhexyl DL-malimide was prepared by the reaction of 2-ethylhexyl amine with DL-malic acid. DL-Malic acid (10.327 g, 77.015 mmole) and toluene (40 mL) were weighed into a 250 mL 3-necked round-bottomed flask equipped with a teflon-coated magnetic stir bar. A Claisen adapter was placed in the center neck, a Dean-Stark trap was placed on top of the Claisen adapter, and a condenser was placed in the neck of the Dean-Stark trap. A nitrogen inlet adapter was placed on the condenser. In the left neck was placed a pressure-equalizing addition funnel containing 2-ethylhexyl amine (9.955 g, 77.02 mmole) and toluene (10 mL, added to ensure complete transfer of the amine). In the right neck was placed a rubber septum which held a thermocouple. The apparatus was purged with nitrogen for 10-15 minutes and then heated to ˜100° C.

Provenance & Evidence