Water → 1,2,3,6-Tetrahydro-1-methyl-4-(2,4,6-trimethoxyphenyl)-3-pyridinol

HRID 2304803Notes

Reaction equation

HRID 2304803 reaction equation
Br.Br[CH:3]1[C:8]([C:9]2[C:14]([O:15][CH3:16])=[CH:13][C:12]([O:17][CH3:18])=[CH:11][C:10]=2[O:19][CH3:20])=[CH:7][CH2:6][N:5]([CH3:21])[CH2:4]1.[OH2:22]>>[OH:22][CH:3]1[C:8]([C:9]2[C:14]([O:15][CH3:16])=[CH:13][C:12]([O:17][CH3:18])=[CH:11][C:10]=2[O:19][CH3:20])=[CH:7][CH2:6][N:5]([CH3:21])[CH2:4]1

Participants

3

Reactant 2

HCID 962WaterHCID 9866952HCID 9866952, compound

Product 1

HCID 99256571,2,3,6-Tetrahydro-1-methyl-4-(2,4,6-trimethoxyphenyl)-3-pyridinol

Procedure

treating the reaction mixture containing the compound (VI) directly with water and reacting by stirring at 50°-100° C., preferably at 60°-80° C., to give 3(R,S)-hydroxy-1-methyl-4-(2,4,6-trimethoxyphenyl)-1,2,3,6-tetrahydropyridine (VII), and

Workup

  1. additiontreating the reaction mixture

Sources & evidence

ORD record
ord-a4d6ec696bd343d88508a4d9bcee9838
Source dataset
uspto-grants-2002_08
Patent number
US06437136B1

Reaction notes

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