反应详情

4-Chloro-2-Ethoxycarbonyl-3,5-Lutidine (1 eq.) was suspended in 10% sodium hydroxide aqueous solution (4 eq.), the mixture was stirred and heated to 80ℑ C. After 4 hours a homogeneoussolution was obtained. The solution was washed with toluene and then acidified to pH 2.5. The white precipitate was extracted with dichloromethane (3×5 volumes). The combined organic extracts were dried over sodium sulfate, filtered and the solvent was evaporated under vacuum. The 2-carboxy-4-chloro-3,5-lutidine product was obtained as an off white solid in 85% yield.

1. temperatureheated to 80ℑ C
2. customAfter 4 hours a homogeneoussolution was obtained
3. washThe solution was washed with toluene
4. extractionThe white precipitate was extracted with dichloromethane (3×5 volumes)
5. dry with materialThe combined organic extracts were dried over sodium sulfate
6. filtrationfiltered
7. customthe solvent was evaporated under vacuum