反应详情

温度

2 °C

190 g (0.380 mol) of 5-methyl-4-[2-(7-amino-benzothiophene-4-yloxy)-ethyl]-2-phenyl-oxazole were suspended in 2.85 l of ethanol. 31.6 g (0.415 mol) of thiourea and 34.8 g of sodium acetate were added. After boiling for about 18 hours (reflux) the reaction mixture was cooled to 0 to 4° C. and stirred for 1.5 hours at this temperature. The precipitate was filtered with suction and washed twice with 250 ml cold ethanol. 1.9 l of water was added to the residue, the mixture was stirred for 10 minutes and the precipitate was filtered with suction and dried for 24 hours at 80° C. (vacuum).

1. temperature(reflux) the reaction mixture
2. filtrationThe precipitate was filtered with suction
3. washwashed twice with 250 ml cold ethanol
4. addition1.9 l of water was added to the residue
5. stirringthe mixture was stirred for 10 minutes
6. filtrationthe precipitate was filtered with suction
7. customdried for 24 hours at 80° C. (vacuum)