HCID 7015801, compound → HCID 22961348, compound

Participants

Reaction Steps

(1R)-1-[(RS)-(2-benzoxazolyl)hydroxymethyl]-3-phenylpropylamine (62 mg) is coupled with N,N′-bis-Boc-D-ornithine (51 mg) to afford the title compound (110 mg) as a glassy solid: 1H NMR (400 MHz, CDCl3, 3:2 mixture of diastereomers) δ 1.39-1.42 (2s, 18H), 1.58 (m, 3H), 1.86 (m, 2H), 2.09 (m, 1H), 2.67-2.78 (m, 1.6H), 2.92 (m, 0.4H), 2.96-3.22 (m, 2H), 4.07 (m, 0.4H), 4.18 (m, 0.6H), 4.59 (m, 1.4H), 4.78 (m, 0.6H), 5.04 (s, 1H), 5.14 (bd, 0.4H, NH), 5.26 (bd, 0.6H, NH), 7.09-7.37 (m, 7H), 7.50 (m, 1H), and 7.71 (m, 1H).

Provenance & Evidence