HCID 7015801, compound → N,N'-Bis-Boc-(2R)-2,5-Diamino-N-[(1R)-1-[(RS)-(5,6-dimethyl-2-benzoxazolyl)hydroxymethyl]-3-phenylpropyl]valeramide

Participants

Reaction Steps

(1R)-1-[(RS)-(5,6-dimethyl-2-benzoxazolyl)hydroxymethyl]-3-phenylpropylamine (157 mg) is coupled with N,N′-bis-Boc-D-ornithine to afford the title compound (343 mg) as a white solid: 1H NMR (400 MHz, CDCl3, 3:2 mixture of diastereomers) δ 1.39-1.43 (bd, 19H), 1.43-1.64 (m, 4H), 1.83 (m, 1H), 2.38 (m, 6H), 2.61-3.21 (m, 4H), 4.08 (m, 1H), 4.59 (m, 1H), 5.02 (s, 1H), 5.18 (bd, 0.6H, NH), 5.28 (bd, 0.4H, NH), 7.12-7.35 (m, 6H), 7.41 (s, 0.4H), and 7.46 (s, 0.6H).

Provenance & Evidence