HCID 7015801, compound → n,n'-Bis-boc-(2r)-2,5-diamino-n-[(1r)-1-[(rs)-(2-benzimidazolyl)hydroxymethyl]-3-phenylpropyl]valeramide

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Reaction Steps

N-Cbz-(1R)-1-[(RS)-(2-Benzimidazolyl)hydroxymethyl]-3-phenylpropylamine (581 mg) is deprotected in trifluoroacetic acid, and the residue is coupled to N,N′-bis-Boc-D-ornithine to afford the title compound (110 mg): mass spectrum (ES+) m/e 596.3 (M+1); 1H NMR (400 MHz, CDCl3, 3:2 mixture of diastereomers) δ 1.46 (m, 9H), 1.42 (s, 9H), 1.58 (m, 4H), 2.02 (m, 2H), 2.63 (m, 2H), 2.82 (m, 2H), 3.18 (m, 1H), 4.16 (m, 1H), 4.49 (m, 1H), 5.17 (m, 1H), 5.42 (m, 1H), 7.03-7.23 (m, 8H), and 7.57 (m, 1H).

Provenance & Evidence