HCID 7015801, compound → n,n'-Bis-boc-(2r)-2,5-diamino-n-[(1r)-1-[(rs)-(2-benzothiazolyl)hydroxymethyl]-3-phenylpropyl]valeramide

Participants

Reaction Steps

(1 R)-1-[(RS)-(2-Benzothiazolyl)hydroxymethyl]-3-phenylpropylamine (72 mg) was coupled to N,N′-bis-Boc-D-ornithine to afford the title compound (11 mg) as a glassy solid: 1H NMR (400 MHz, CDCl3, 3:2 mixture of diastereomers) δ 1.41 (s, 9H), 1.44 (s, 9H), 1.60 (m, 2H), 1.19 (m, 4H), 2.20 (m, 2H), 2.72-2.91 (m, 2H), 4.11 (m, 1H), 4.31 (m, 0.4H), 4.41 (m, 0.6H), 5.06 (m, 0.6H), 5.19 (d, J=1.1 Hz, 0.4H), 7.20 (m, 3H), 7.26 (m, 2H), 7.40 (t, J=8.5 Hz, 1H), 7.49 (t, J=9.3 Hz, 1H), 7.87 (d, J=8.3 Hz, 1H), and 7.98 (d, J=9.4 Hz, 1H).

Provenance & Evidence