HCID 23512804, compound → HCID 178520460, compound

HRID 2304931Notes

Reaction equation

HRID 2304931 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]([NH:12][CH2:13][CH:14]2[CH2:41][CH2:40][C:17]3[N:18](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[CH:19]=[N:20][C:16]=3[CH2:15]2)=[O:11])=[CH:4][CH:3]=1>C(O)(=O)C.O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][C:10]([NH:12][CH2:13][CH:14]2[CH2:41][CH2:40][C:17]3[NH:18][CH:19]=[N:20][C:16]=3[CH2:15]2)=[O:11])=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 23512804HCID 23512804, compound

Product 1

HCID 178520460HCID 178520460, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent

Conditions

Temperature
90 °C

Procedure

A solution of a mixture of 3-(4-chlorophenyl)-N-((1-triphenylmethyl-4,5,6,7-tetrahydro-1H-benzimidazol-5-yl)methyl)propionamide and 3-(4-chlorophenyl)-N-((3-triphenylmethyl-4,5,6,7-tetrahydro-3-triphenylmethyl-4,5,6,7-tetrahydro-3H-benzimidazol-5-yl)methyl)propionamide (0.69 g, 1.23 mmol) in acetic acid (5 ml) and water (0.6 ml) was heated to 90° C. for 1.5 hours. The solvent was removed in vacuo. The crude product was purified by flash chromatography on silica (40 g), using DCM/methanol/25% aqueous ammonia (100:10:1) as eluent, to give 0.42 g of the title compound.

Workup

  1. customThe solvent was removed in vacuo
  2. customThe crude product was purified by flash chromatography on silica (40 g)

Sources & evidence

ORD record
ord-a154871593974cacb9a32114b4f7d779
Source dataset
uspto-grants-2002_08
Patent number
US06437147B1

Reaction notes

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