1-Octanol → Glycidyl n-octyl ether

Temperature

0 °C

Octanol (130 g) and 2.84 g of a boron trifluorideether complex were cooled to 0° C. while stirring. At a temperature maintained at 0° C., 138.8 g of epichlorohydrin was added dropwise over 1 hour. After completion of dropwise addition, an excess alcohol was distilled off at 100° C. under reduced pressure (13 to 26 Pa). The reaction mixture was cooled to 50° C. and while maintaining the temperature at 50° C., 125 g of a 48% aqueous solution of sodium hydroxide was added dropwise over 1 hour. After stirring for 3 hours, 200 mL of water was added to the reaction mixture to cause separation. The water layer thus obtained was removed and then the residue was washed twice with 100 mL of water, whereby 208 g of crude octyl glycidyl ether was obtained.

1. additionAfter completion of dropwise addition
2. distillationan excess alcohol was distilled off at 100° C. under reduced pressure (13 to 26 Pa)
3. temperatureThe reaction mixture was cooled to 50° C.
4. temperaturewhile maintaining the temperature at 50° C.
5. addition125 g of a 48% aqueous solution of sodium hydroxide was added dropwise over 1 hour
6. stirringAfter stirring for 3 hours
7. addition200 mL of water was added to the reaction mixture
8. customseparation
9. customThe water layer thus obtained
10. customwas removed
11. washthe residue was washed twice with 100 mL of water

ORD record

ord-1d6273ad3b1349c3b3cc5b157232fe13

Source dataset

uspto-grants-2002_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06437196B1