Sodium Hydroxide → 3-(Pentyloxy)propane-1,2-diol
Reaction equation
[CH2:1]([O:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])[CH:2]1[O:4][CH2:3]1.[OH-:11].[Na+]>C(O)(=O)CCCCC(O)=O.[OH-].[Na+].O>[CH2:1]([O:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])[CH:2]([CH2:3][OH:11])[OH:4]Participants
6
Reactant 2
Product 1
Reagents, catalysts & solvents 3
Conditions
- Temperature
- 200 °C
Procedure
In an autoclave, 163 g of the crude pentyl glycidyl ether, 108 g of water, 7.3 g of adipic acid and 10.4 g of sodium hydroxide were charged. The resulting mixture was heated to 200° C. while stirring. After stirring for 2 hours, 1.6 g of sodium hydroxide was added. The resulting reaction mixture was dehydrated at 100° C. under reduced pressure (5.32 kPa), followed by purification by distillation under reduced pressure (133 to 266 Pa, 114 to 115° C.) , whereby 117 g of monopentyl glyceryl ether was obtained. As a result of GLC, it was found that the resulting compound had a purity not less than 99% and the content of organochlorine compounds was not greater than 100 ppm.
Workup
- stirringAfter stirring for 2 hours
- customThe resulting reaction mixture
- customwas dehydrated at 100° C. under reduced pressure (5.32 kPa)
- distillationfollowed by purification by distillation under reduced pressure (133 to 266 Pa, 114 to 115° C.)
Sources & evidence
- ORD record
- ord-2138e957bc58453b8473f80c1718ac39
- Source dataset
- uspto-grants-2002_08
- Patent number
- US06437196B1
Reaction notes
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