HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl methylphosphonate → 1,1-Difluoro-3-amino-3-hydroxymethyl-5-(4-octylphenyl)pentylphosphonic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl methylphosphonate | HCID 12958 | — |
| Reactant | Fingolimod | HCID 107970 | — |
| Reactant | Phosphonic acid, (difluoromethyl)-, diethyl ester | HCID 2758305 | — |
| Reactant | Lithium | HCID 3028194 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Product | 1,1-Difluoro-3-amino-3-hydroxymethyl-5-(4-octylphenyl)pentylphosphonic acid | HCID 10202364 | — |
Reaction Steps
The title compound was prepared from 2-amino-2-hydroxymethyl-4-(4-(octyl)phenyl)butanol (FrY 720) using procedures analogous to those described in EXAMPLE 2, except that lithium dilsopropylamide was substituted for n-butyllithium in Step C and diethyl difluoromethylphosphonate was substituted for dimethyl methylphosphonate in Step C: Mass spectrum (NH3—CI) 422 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06437165B1 |
| Source dataset | uspto-grants-2002_08 |
| ORD ID | ord-d345444460274bfca6870ab5e5a72191 |
| Source note | uspto-grants-2002_08 |