Sodium Hydroxide → HCID 18459324, compound

Participants

Reaction Steps

To a solution of 2-hydroxy-2-[(4-methoxybenzenesulfonyl)methyl]-3-(4-phenylbenzenesulfonyl)propionic acid, ethyl ester (0.70 g, 1.3 mmol) in 25 mL of methanol is added sodium hydroxide (25 mmol in 10 mL of water). The reaction mixture is stirred at ambient temperature for 1 hour, and then quenched by the addition of 25 mL of 1N HCl. Methanol is removed under reduced pressure, and the product is extracted with several portions of ethyl acetate. The organic phase is washed with brine, dried over magnesium sulfate, filtered, and concentrated to afford the title compound as a white solid.

Provenance & Evidence