4-Nitrobenzenesulfonyl chloride → HCID 10207520, compound

HRID 230509Notes

Reaction equation

HRID 230509 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:14][CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]2)=[CH:4][C:3]=1[NH:22][S:23]([CH3:26])(=[O:25])=[O:24].[N+:27]([C:30]1[CH:35]=[CH:34][C:33]([S:36]([Cl:39])(=[O:38])=[O:37])=[CH:32][CH:31]=1)([O-:29])=[O:28]>>[ClH:39].[N:8]1([C:5]2[CH:6]=[CH:7][C:2]([NH:1][S:36]([C:33]3[CH:32]=[CH:31][C:30]([N+:27]([O-:29])=[O:28])=[CH:35][CH:34]=3)(=[O:37])=[O:38])=[C:3]([NH:22][S:23]([CH3:26])(=[O:24])=[O:25])[CH:4]=2)[CH2:14][CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 74044-Nitrobenzenesulfonyl chlorideHCID 22272520HCID 22272520, compound

Product 1

HCID 10207520HCID 10207520, compound

Procedure

The compound was synthesized from N-{2-amino-5-(4-t-butyloxycarbonyl-1,4-diazepan-1-yl)-phenyl}methanesulfonamide and 4-nitrobenzenesulfonylchloride (101 mg, 0.455 mmol) according to general method 3 to give before Boc-deprotection 118 mg of a purple solid. M+1 470.1 Calcd 470.11.

Workup

  1. customto give before Boc-deprotection 118 mg of a purple solid

Sources & evidence

ORD record
ord-3ce9a45949ee4277849d92b7421d17bb
Source dataset
uspto-grants-2009_07
Patent number
US07566715B2

Reaction notes

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