HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → 5-bromo-6-fluoro-3-(1-BOC-2-(S)-pyrrolidinylmethoxy)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | (S)-(-)-N-Boc-prolinol | HCID 643448 | — |
| Reactant | Diethyl azodicarboxylate | HCID 5462977 | — |
| Reactant | 5-Bromo-6-fluoropyridin-3-ol | HCID 18458777 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-bromo-6-fluoro-3-(1-BOC-2-(S)-pyrrolidinylmethoxy)pyridine | HCID 22872670 | — |
Reaction Steps
A sample of 1-BOC-2-(S)-pyrrolidinemethanol, prepared as described above, and of 3-bromo-2-fluoro-5-hydroxypyridine, prepared as in step b above, are reacted with triphenylphosphine and DEAD in THF at room temperature for 16 hours, to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06437138B1 |
| Source dataset | uspto-grants-2002_08 |
| ORD ID | ord-bfc02cdd77cc4770a444af3225f568dd |
| Source note | uspto-grants-2002_08 |