Hydrochloric Acid → HCID 9860821, compound

Participants

Reaction Steps

To a solution of 5-ethenyl-3-(1-methyl-2-(S)-pyrrolidinyl-methoxy)pyridine from step b above in Et2O was added hydrogen chloride (1.0 M in Et2O) carefully to afford the tittle compound: mp 118-120° C.; 1H NMR (D2O) δ 2.56-2.76 (m, 3H), 3.00 (s, 3H), 4.03 (q, 1H, J=9.5 Hz), 4.29 (m, 1H), 4.52 (dd, 1H, J=5.5, 12.0 Hz), 4.60 (dd, 1H, J=3.0, 11.5 Hz), 5.65 (d, 1H, J=11.0 Hz), 6.09 (d, 1H, J=17.5 Hz), 6.84 (d, 1H, (dd, 1H, J=11.0, 17.5 Hz), 8.02 (t, 1H, J=2.0 Hz), 8.36 (d, 1H, J=3.0 Hz), 8.43 (d, 1H, J=1.0 Hz); MS (CI/NH3) mn/z 205 (N+H)+. Anal. Calcd for C12H16N2O.1.9 HCl: C, 50.69; H, 6.77; N, 9.85. Found: C, 50.79; H, 7.05; N, 9.48. [α]25D −20.43 (c 0.7, MeOH).

Provenance & Evidence