Hydrochloric Acid → HCID 22961902, compound

Participants

Reaction Steps

To a solution of 6-chloro-3-(1-methyl-2-(S)-azetidinyl-methoxy)-5-(5-pyrimidinyl)pyridine in Et2O was added hydrogen chloride (1.0 M in Et2O) carefully to afford the tittle compound: mp 143-144° C.; 1H NMR (D2O) δ 2.56-2.76 (m, 2H), 3.80 (m, 1H), 4.26 (m, 1H), 4.44-4.58 (m, 2H), 4.79 (m, 1H), 7.70 (d, 1H, J=3.0 Hz), 8.28 (d, 1H, J=3.0 Hz), 9.00 (s, 2H), 9.22 (s, 1H); MS (CI/NH3) m/z 291 (M+H)+. Anal. Calcd for C14H15ClN4O.HCl: C, 51.39; H, 4.93; N, 17.12. Found: C, 51.51; H, 4.80; N, 16.82. [α]25D −16.33 (c 0.74, MeOH).

Provenance & Evidence