Hydrochloric Acid → HCID 86755890, compound

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Reaction Steps

To a solution of 6-chloro-3-(1-methyl-2-(R)-pyrrolidinylmethoxy)-5-(5-pyrimidinyl)pyridine in Et2O was added hydrogen chloride (1.0 M in Et2O) carefully to afford the tittle compound: mp 195-197° C.; 1H NMR (D2O) δ 2.02-2.18 (m, 2H), 2.24 (m, 1H), 2.40 (m, 1H), 3.05 (s, 3H), 3.26 (m, 1H), 3.36 (m, 1H), 3.95 (m, 1H), 4.40 (dd, 1H, J=6.0, 11.0 Hz), 4.57 (dd, 1H, J=3.0, 10.0 Hz), 7.66 (d, 1H, J=3.0 Hz), 8.24 (d, 1H, J=3.0 Hz), 8.99 (s, 2H), 9.21 (s, 1H), MS (CI/NH3) m/z 306 (M+H)+. Anal. Calcd for C15H17CIN4O.1.6 HCl.0.1 H2O: C, 49.37; H, 5.19; N, 15.35. Found: C, 49.55; H, 5.13; N, 15.02. [α]25D+8.1 (c 1.2, MeOH).

Provenance & Evidence