Hydrochloric Acid → HCID 22961865, compound

Participants

Reaction Steps

The product of step 212a (0.18 g, 0.40 mmol) was deprotected and isolated as the free base in 37% yield according to the procedure of Example 20b, followed by conversion to the dihydrochloride with excess HCl/Et20. 1H NMR (D2O, 300 MHz) δ 2.62-2.71 (q, J=8.5, 17.0 Hz, 2H), 4.01-4.18 (m, 2H), 4.41 (d, J=4.0 Hz, 2H), 4.65 (s, 2H), 4.88 (m, 1H), 7.57 (d, J=3.0 Hz, 1H), 7.78 (t, J=3.0 Hz, 1H), 8.09 (d, J=3.0 Hz, 1H), 8.19 (d, J=9.0 Hz, 1H), 8.43 (d, J=8.5 Hz, 1H), 8.61 (t, J=2.0 Hz, 1H); MS (CI/NH3) m/z 377 (M+H)+. Anal. Calcd for C17H17ClN4O4.2 HCl.H2O: C, 43.65; H, 4.53; N, 11.98. Found: C, 43.97; H, 4.54; N, 11.53.

Provenance & Evidence