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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2305233Generated: October 31, 2026

Hydrochloric Acid → HCID 70105295, compound

https://huagongshe.com/reaction/2305233

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantHCID 70105296HCID 70105296—
SolventDiethyl EtherHCID 3283—
SolventEthyl AcetateHCID 8857—
ProductHCID 70105295HCID 7010529597%

Reaction Steps

To a solution of (S)-N-[2-(2-pyridyl)ethyl]-3-{[2-(4,5-diphenyloxazol-2-yl)-2-cyclohexen-1-yl]methyl}benzamide (130 mg, 0.241 mmol) in ethyl ether (4 ml) was added 4N hydrogen chloride in EtOAc (0.5 ml) at room temperature. The solvent was removed in vacuo and the resulting solid was collected, washed with ethyl ether, and dried to give (S)-N-[2-(2-pyridyl)ethyl]-3-{[2-(4,5-diphenyloxazol-2-yl)-2-cyclohexen-1-yl]methyl}benzamide hydrochloride (135.2 mg, 97%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06437146B1
Source datasetuspto-grants-2002_08
ORD IDord-27b33b33b45a4ee18d5e383024fcae9e
Source noteuspto-grants-2002_08