HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 70105295, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 70105296 | HCID 70105296 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 70105295 | HCID 70105295 | 97% |
Reaction Steps
To a solution of (S)-N-[2-(2-pyridyl)ethyl]-3-{[2-(4,5-diphenyloxazol-2-yl)-2-cyclohexen-1-yl]methyl}benzamide (130 mg, 0.241 mmol) in ethyl ether (4 ml) was added 4N hydrogen chloride in EtOAc (0.5 ml) at room temperature. The solvent was removed in vacuo and the resulting solid was collected, washed with ethyl ether, and dried to give (S)-N-[2-(2-pyridyl)ethyl]-3-{[2-(4,5-diphenyloxazol-2-yl)-2-cyclohexen-1-yl]methyl}benzamide hydrochloride (135.2 mg, 97%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06437146B1 |
| Source dataset | uspto-grants-2002_08 |
| ORD ID | ord-27b33b33b45a4ee18d5e383024fcae9e |
| Source note | uspto-grants-2002_08 |