Phenethylamine → HCID 9808232, compound

Participants

Reaction Steps

To a solution of 2-phenylethylamine (0.082 ml, 0.65 mmol) and triethylamine (0.097 ml, 0.70 mmol) in methylene chloride (3 ml) was added a solution of crude 3-{[2-(4,5-diphenyloxazol-2-yl)-2-cyclohexen-1-yl]methyl}benzenesulfonyl chloride (213 mg, 0.44 mmol) in methylene chloride (3 ml) at 5° C. After stirring at room temperature for 1 hour, the reaction mixture was diluted with EtOAc, washed with 1N hydrochloric acid, water, saturated sodium hydrogencarbonate solution, water and brine, dried over magnesium sulfate, and evaporated in vacuo. The residue was purified by silica gel column chromatography (hexane:EtOAc, 5:1-3:1 elution) to give 3-{[2-(4,5-diphenyloxazol-2-yl)-2-cyclohexen-1-yl]methyl}-N-(phenethyl)benzenesulfonamide (54.3 mg, 22%).

Provenance & Evidence