反应详情

To a solution of (±)-3-{[2-(4,5-diphenyloxazol-2-yl)-2-cyclohexen-1-yl]methyl}phenylamine (110 mg, 0.27 mmol) in methylene chloride (3 ml) was added benzenesulfonylisocyanate (0.037 ml, 0.27 mmol) at 5° C., and the mixture was stirred at room temperature for 1 hour. The reaction mixture was evaporated, and the residue was purified by silica gel column chromatography (methylene chloride-MeOH, 30:1 elution) to give (±)-1-benzenesulfonyl-3-{3-{[2-(4,5-diphenyloxazol-2-yl)-2-cyclohexen-1-yl]methyl}phenyl}urea (159.0 mg, 100%).

1. customThe reaction mixture was evaporated
2. customthe residue was purified by silica gel column chromatography (methylene chloride-MeOH, 30:1 elution)