Hydrochloric Acid → HCID 9953753, compound

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Reaction Steps

A mixture of (±)-N-[3-([1,1′-biphenyl]-4-yl)-3-phenylpropyl]-N′-methyl-N′-(phenylmethyl)-1,2-ethanediamine (0.006 mol) in methanol (150 ml) was hydrogenated at room temperature with palladium on carbon (10%, 1 g) as a catalyst. After uptake of hydrogen (1 equivalent), the catalyst was filtered off and the filtrate was evaporated, giving a residue that was converted into the hydrochloric acid salt (1:2) with HCl/2-propanol, yielding 2.76 g of (±)-N-[3-([1,1′-biphenyl]-4-yl)-3-phenylpropyl]-N′-methyl-1,2-ethanediamine dihydrochloride (comp. 56).

Provenance & Evidence