Benzene → HCID 70147664, compound

Participants

Reaction Steps

In the presence of a catalytic amount of acetic acid, 2,3-dicyano-5-hydroxy-5-phenyl-7-methyl-4H-1,4-diazepine (compound 5a) was obtained by reacting 1 mol of diaminomaleonitrile with 1 mol of acetylacetone in a solvent (benzene) at 45° C. for 6 hours. The diazepine compound (5a) thus obtained was dehydrated in the presence of phosphorus pentoxide. The object compound 2,3-dicyano-5-phenyl-7-(2-(4-methoxyphenyl)vinyl-1-yl)-6H-1,4-diazepine (compound 5) was obtained by reacting the diazepine compound (5b) thus obtained with 4-methoxybenzaldehyde in the presence of piperidine.

Provenance & Evidence