Tetrahydrofuran → HCID 22650052, compound

Participants

Reaction Steps

A total of 10 mmole of acrylic chloride was added dropwise to a mixture of 10 mmole of the above-prepared 3-hydroxy-α,α-dimethyl-1-adamantanemethanol, 10 mmole of triethylamine, and 40 ml of tetrahydrofuran ,over about 30 minutes. After the completion of addition, the resulting mixture was stirred at room temperature for 6 hours. Water was added to the reaction mixture and the mixture was concentrated, and the concentrate was subjected to column chromatography on a silica gel to yield the title compound in a yield of 23%.

Provenance & Evidence