Ammonia → HCID 9820407, compound

Participants

Reaction Conditions

Reaction Steps

Compound 12 (50 mg, 0.1 mmol) was dissolved in 5 mL methanolic ammonia (saturated at 0° C.) and the mixture was heated at 40° C. for 24 h. After concentration in vacuo, the residue was purified using prep. TLC (10% MeOHIDCM) to afford 13 1HNMR (CD3OD)δ2.5 (s, 3 H) 3.75 (d, 1 H), 3.85 (d, 1 H), 4.15 (d, 2 H) 4.45 (m, 1 H), 4.85 (m, 1 H), 6.0 (d, 1 H), 6.75 (d, 1 H), 7.7 (d, 1 H), 8.25 (s, 1 H).

Provenance & Evidence