HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → HCID 178486090, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Tert-Butyl nitrite | HCID 10906 | — |
| Reactant | HF-Pyridine | HCID 13989026 | — |
| Reactant | HCID 178486091 | HCID 178486091 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 178486090 | HCID 178486090 | — |
Reaction Steps
The compound 3-amino-4-methyl-benzene-N,N-dimethylsulfonamide is diazotized with an alkyl nitrite like tert-butyl nitrite under anhydrous conditions in a non-reactive solvent like tetrahydrofuran or dichloromethane. The intermediate diazonium species is then treated with pyridinium fluoride to give the product, which may be purified by chromatography or crystallization.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06440966B1 |
| Source dataset | uspto-grants-2002_08 |
| ORD ID | ord-5500d3370cc4441082f5c52a2629134f |
| Source note | uspto-grants-2002_08 |