HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → 6-Amino-1-(4-chloro-benzyl)-1H-pyrimidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | HCID 18432836 | HCID 18432836 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 6-Amino-1-(4-chloro-benzyl)-1H-pyrimidine-2,4-dione | HCID 1526620 | 98.6% |
Reaction Steps
155.6 g of 1-(4-chlorobenzyl)-3-cyanoacetyl-urea in 230 ml of 2-propanol were added to a solution of 14.0 g of KOH in 450 ml of 2-propanol and heated under reflux for 1 hour. After cooling the solid was collected and washed to give the title compound (153.4 g) as a white solid mp 238-41° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06440979B1 |
| Source dataset | uspto-grants-2002_08 |
| ORD ID | ord-db6ebdaf8ab44bb090203e6b7832903b |
| Source note | uspto-grants-2002_08 |