Sodium Hydroxide → 3-[(4-Chlorophenyl)methyl]-1,3,6,9-tetrahydro-6-thioxo-2H-purin-2-one

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Reaction Conditions

Reaction Steps

11.06 g of 3-(4-chlorobenzyl)-xanthine and 11.34 g of phosphorus pentasulfide were heated under reflux in 112 ml of pyridine for 4 hours. After cooling to 10° C., 52 ml of 2N NaOH were added over 30 minutes. The mixture was evaporated to dryness, the residue suspended in 120 ml of water and the pH adjusted to 7.5. The solid was collected, redissolved in 150 ml of 1N NaOH, treated with 0.6 g of charcoal, filtered and neutralized to pH 7.0. The solid was collected again to give the title compound (10.07 g) mp 313-7° C.;

Provenance & Evidence