Ethylamine → HCID 12050169, compound

HRID 2305391Notes

Reaction equation

HRID 2305391 reaction equation
[CH:1]1([C:4]2[NH:12][C:11]3[C:10](=S)[NH:9][C:8](=[O:14])[N:7]([CH2:15][CH3:16])[C:6]=3[N:5]=2)[CH2:3][CH2:2]1.[CH2:17]([NH2:19])[CH3:18]>O>[CH:1]1([C:4]2[NH:12][C:11]3[C:10]([NH:19][CH2:17][CH3:18])=[N:9][C:8](=[O:14])[N:7]([CH2:15][CH3:16])[C:6]=3[N:5]=2)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 6341EthylamineHCID 18432831HCID 18432831, compound

Product 1

HCID 12050169HCID 12050169, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

5.91 g of 8-cyclopropyl-3-ethyl-6-thioxanthine and 100 ml of 70% ethylamine in water were heated in a 450 ml reactor to 150° C. After 6 hours the solution was filtered and evaporated to dryness. The residue was suspended in methanol, collected, washed and dried to give the title compound (5.67 g) as an off-white solid mp 260° subl./301-5° C. The hydrochloride salt was also obtained as an off-white solid mp 205-50° C.

Workup

  1. filtrationAfter 6 hours the solution was filtered
  2. customevaporated to dryness
  3. customcollected
  4. washwashed
  5. customdried

Sources & evidence

ORD record
ord-920b7aad9c904f87a6ed6373c3c3991b
Source dataset
uspto-grants-2002_08
Patent number
US06440979B1

Reaction notes

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