4-Bromo-1,2-dichlorobenzene → 2-Chloro-4-(3,4-dichlorophenyl)-6-trifluoromethylpyrimidine

HRID 2305396Notes

Reaction equation

HRID 2305396 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][N:3]=1.[Cl:12][C:13]1[CH:14]=[C:15](Br)[CH:16]=[CH:17][C:18]=1[Cl:19]>>[Cl:1][C:2]1[N:3]=[C:4]([C:16]2[CH:15]=[CH:14][C:13]([Cl:12])=[C:18]([Cl:19])[CH:17]=2)[CH:5]=[C:6]([C:8]([F:11])([F:9])[F:10])[N:7]=1

Participants

3

Reactant 2

HCID 290134-Bromo-1,2-dichlorobenzeneHCID 27739122-Chloro-4-(trifluoromethyl)pyrimidine

Product 1

HCID 154777402-Chloro-4-(3,4-dichlorophenyl)-6-trifluoromethylpyrimidine

Procedure

4A was prepared from 2-chloro-4-trifluoromethyl-pyrimidine and 3,4-dichlorobromobenzene by the method reported for 1A. (Method A) 1H NMR 1H, (8.29, 8.28, d) 1H, (8.01, 8.00, 7.98, 7.97, dd) 1H, (7.92, s) 1H, (7.66,7.63, d).

Sources & evidence

ORD record
ord-e702ac3941d2487f84530b83574f5b32
Source dataset
uspto-grants-2002_08
Patent number
US06440984B1

Reaction notes

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