Galactaric acid → HCID 131723457, compound

Participants

Reaction Steps

A solution of (1S,4S)-(5-(4-methoxyphenoxy)-3-pyridyl)-2-N-(tert-butoxycarbonyl)-2,5-diazabicyclo[2.2.1]heptane (0.26 g, 0.87 mmol) in ethanol (2 mL) and water (2 mL) was heated at 60° C. as mucic acid (0.075 g, 0.0574 mmol) was added. The mixture was heated for 30 min then filtered through glass wool and concentrated to approximately 1 mL. The solution was treated with diethyl ether (4 mL). The resulting precipitate was collected, washed with diethyl ether (1 mL) and dried at 45° C. for 4 h. to afford (0.195 g, 68%) of white solid, mp 172-182° C. (d).

Provenance & Evidence