Galactaric acid → HCID 131723458, compound

Participants

Reaction Steps

A solution of (1S,4S)-(5-pyrimidinyl)-2,5-diazabicyclo[2.2.1]heptane (0.15 g, 0.851 mmol) in methanol (3 mL) and water (3 mL) was heated at 60° C. as mucic acid (0.09 g, 0.425 mmol) was added. The mixture was heated for 30 min. then filtered through glass wool and concentrated to approximately 1 mL. The treated with diethyl ether (5 mL), then the precipitate was collected, washed with diethyl ether (1 mL) and dried at 45° C. for 4 h to afford (0.142 g, 59%) of white solid, mp 152-172° C. (d).

Provenance & Evidence