反应详情

A solution of 281.2 mg (0.5 mmol) of 2-phenyl-10,12,15,16-tetrahydroxy-8-methoxy-11-methyl-9,14-dioxo-6,7,9,14-tetrahydronaphthaceno[1,2-g]phthalazin-1-one (5) in 2 m of 2 M sodium hydroxide solution is diluted with 5 m of water. This solution is equilibrated at 5° C. and, while stirring, 2 m of methyl chloroformate are added. The mixture is subsequently stirred at room temperature for 30 min and then neutralized with acetic acid. The precipitated product is filtered off with suction to obtain 260 mg of the product. The yield is 84% of theory.

1. customis equilibrated at 5° C.
2. stirringThe mixture is subsequently stirred at room temperature for 30 min
3. filtrationThe precipitated product is filtered off with suction