Ethyl 3-(3-nitropyridin-2-yl)-2-oxopropionate → ethyl 1H-pyrrolo(3,2-b)pyridine-2-carboxylate

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Reaction Steps

18.4 g of ethyl 3-(3-nitropyridin-2-yl)-2-oxopropionate and 5.5 g of 10% palladium-on-charcoal are added to 500 ml of ethanol, and the reaction mixture is hydrogenated under 2 bar for 3 hours at 20° C. The reaction mixture is then filtered over a thin layer of silica gel and the filtrate is concentrated under reduced pressure, to give 14.1 g of ethyl 1H-pyrrolo[3,2-b]-pyridine-2-carboxylate, the characteristics of which are as follows:

Provenance & Evidence