m-Toluidine → Ethyl 7-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate

HRID 2305453Notes

Reaction equation

HRID 2305453 reaction equation
C(O[CH2:4][CH:5]([C:11]([O:13]CC)=O)[C:6]([O:8][CH2:9][CH3:10])=[O:7])C.[NH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([CH3:23])[CH:18]=1>C1C=CC(C2C=CC=CC=2)=CC=1.C1C=CC(OC2C=CC=CC=2)=CC=1>[OH:13][C:11]1[C:22]2[C:17](=[CH:18][C:19]([CH3:23])=[CH:20][CH:21]=2)[N:16]=[CH:4][C:5]=1[C:6]([O:8][CH2:9][CH3:10])=[O:7]

Participants

4

Reactant 2

HCID 7934m-ToluidineHCID 98702Diethyl (ethoxymethyl)malonate

Product 1

HCID 178469524Ethyl 7-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylateYield 76.3%

Reagents, catalysts & solvents 1

HCID 246701,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene)Solvent

Conditions

Temperature
100 °C

Procedure

Diethyl ethoxymethylmalonate (37.8 mL, 187 mmol) and m-toluidine (20.0 mL, 187 mmol) were combined and heated at 100° C. for about 3 hours. The reaction mixture was allowed to cool to ambient temperature and it solidified. Dowtherm A (350 mL) was added and the reaction mixture was heated at reflux for about 30 minutes. The reaction mixture was allowed to cool to ambient temperature. The resulting precipitate was isolated by filtration, rinsed with acetone and dried to provide 33 g of ethyl 4-hydroxy-7-methyl-3-quinolinecarboxylate as a tan powder.

Workup

  1. temperatureto cool to ambient temperature
  2. temperaturethe reaction mixture was heated
  3. temperatureat reflux for about 30 minutes
  4. temperatureto cool to ambient temperature
  5. customThe resulting precipitate was isolated by filtration
  6. washrinsed with acetone
  7. customdried

Sources & evidence

ORD record
ord-b0b2974624824321958800a10c107d0d
Source dataset
uspto-grants-2002_08
Patent number
US06440992B1

Reaction notes

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