Nitric Acid → HCID 178422973, compound

HRID 2305455Notes

Reaction equation

HRID 2305455 reaction equation
[N+:1]([O-:4])(O)=[O:2].[CH3:5][C:6]1[CH:15]=[C:14]2[C:9]([C:10]([OH:16])=[CH:11][CH:12]=[N:13]2)=[CH:8][CH:7]=1>C(O)(=O)CC>[CH3:5][C:6]1[CH:15]=[C:14]2[C:9]([C:10]([OH:16])=[C:11]([N+:1]([O-:4])=[O:2])[CH:12]=[N:13]2)=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 178422955HCID 178422955, compound

Product 1

HCID 178422973HCID 178422973, compound

Reagents, catalysts & solvents 1

HCID 1032Propionic AcidSolvent

Procedure

Nitric acid (6 mL of 70%) was slowly added to a hot (125° C.) solution of 7-methyl-4-quinolinol (10.5 g) in propionic acid (125 mL). The reaction mixture was stirred for about 1.5 hours and then it was allowed to cool to ambient temperature. The resulting precipitate was isolated by filtration, rinsed well with ethanol and water and then dried to provide 6.9 g of 7-methyl-3-nitro-4-quinolinol as a pale yellow solid.

Workup

  1. customThe resulting precipitate was isolated by filtration
  2. washrinsed well with ethanol and water
  3. customdried

Sources & evidence

ORD record
ord-5edc39d31ad54297b53aa6297773d6cc
Source dataset
uspto-grants-2002_08
Patent number
US06440992B1

Reaction notes

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